Bone Broth Scientific Studies

Here’s our growing collection of Bone broth and collagen scientific studies…

  1. Mar-Solís, L. M., Soto-Domínguez, A., Rodríguez-Tovar, L. E., Rodríguez-Rocha, H., García-García, A., Aguirre-Arzola, V. E., Zamora-Ávila, D. E., Garza-Arredondo, A. J., & Castillo-Velázquez, U. (2021). Analysis of the anti-inflammatory capacity of bone broth in a murine model of ulcerative colitis. Medicina, 57(11), 1138. https://doi.org/10.3390/medicina57111138
  1. Hawkins, J., & Durham, P. (2018). Enriched chicken bone broth as a dietary supplement reduces Nociception and sensitization associated with prolonged jaw opening. Journal of Oral & Facial Pain and Headache, 32(2), 208-215. https://doi.org/10.11607/ofph.1971
  1. Heaton, L. E., Davis, J. K., Rawson, E. S., Nuccio, R. P., Witard, O. C., Stein, K. W., Baar, K., Carter, J. M., & Baker, L. B. (2017). Selected in-season nutritional strategies to enhance recovery for team sport athletes: A practical overview. Sports Medicine, 47(11), 2201-2218. https://doi.org/10.1007/s40279-017-0759-2
  1. Hsu, D., Lee, C., Tsai, W., & Chien, Y. (2017). Essential and toxic metals in animal bone broths. Food & Nutrition Research, 61(1), 1347478. https://doi.org/10.1080/16546628.2017.1347478
  1. León-López, A., Morales-Peñaloza, A., Martínez-Juárez, V. M., Vargas-Torres, A., Zeugolis, D. I., & Aguirre-Álvarez, G. (2019). Hydrolyzed collagen—Sources and applications. Molecules, 24(22), 4031. https://doi.org/10.3390/molecules24224031
  1. Liu, D., Nikoo, M., Boran, G., Zhou, P., & Regenstein, J. M. (2015). Collagen and gelatin. Annual Review of Food Science and Technology, 6(1), 527-557. https://doi.org/10.1146/annurev-food-031414-111800
  1. Razak, M. A., Begum, P. S., Viswanath, B., & Rajagopal, S. (2017). Multifarious beneficial effect of nonessential amino acid, glycine: A review. Oxidative Medicine and Cellular Longevity, 2017, 1-8. https://doi.org/10.1155/2017/1716701
  1. Scaldaferri, F., Lopetuso, L. R., Petito, V., Cufino, V., Bilotta, M., Arena, V., Stigliano, E., Maulucci, G., Papi, M., Emiliana, C. M., Poscia, A., Franceschi, F., Delogu, G., Sanguinetti, M., Spirito, M. D., Sgambato, A., & Gasbarrini, A. (2014). Gelatin tannate ameliorates acute colitis in mice by reinforcing mucus layer and modulating gut microbiota composition: Emerging role for ‘gut barrier protectors’ in IBD? United European Gastroenterology Journal, 2(2), 113-122. https://doi.org/10.1177/2050640614520867
  2. Li, P., & Wu, G. (2017). Roles of dietary glycine, proline, and hydroxyproline in collagen synthesis and animal growth. Amino Acids, 50(1), 29-38. https://doi.org/10.1007/s00726-017-2490-6
  1. Henrotin, Y., Mobasheri, A., & Marty, M. (2012). Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis? Arthritis Research & Therapy, 14(1), 201. https://doi.org/10.1186/ar3657
  1. Bishnoi, M., Jain, A., Hurkat, P., & Jain, S. K. (2016). Chondroitin sulphate: A focus on osteoarthritis. Glycoconjugate Journal, 33(5), 693-705. https://doi.org/10.1007/s10719-016-9665-3
  1. Lidong, W. (2020). Effect of tai chi on patients with knee osteoarthritis: An updated systematic review and meta-analysis. https://doi.org/10.37766/inplasy2020.7.0033
  1. Singh, J. A., Noorbaloochi, S., MacDonald, R., & Maxwell, L. J. (2015). Chondroitin for osteoarthritis. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.cd005614.pub2
  1. Kumar, S., Sugihara, F., Suzuki, K., Inoue, N., & Venkateswarathirukumara, S. (2014). A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis. Journal of the Science of Food and Agriculture, 95(4), 702-707. https://doi.org/10.1002/jsfa.6752
  1. Leidy, H. J., Clifton, P. M., Astrup, A., Wycherley, T. P., Westerterp-Plantenga, M. S., Luscombe-Marsh, N. D., Woods, S. C., & Mattes, R. D. (2015). The role of protein in weight loss and maintenance. The American Journal of Clinical Nutrition, 101(6), 1320S-1329S. https://doi.org/10.3945/ajcn.114.084038
  1. Zdzieblik, D., Oesser, S., Baumstark, M. W., Gollhofer, A., & König, D. (2015). Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: A randomised controlled trial. British Journal of Nutrition, 114(8), 1237-1245. https://doi.org/10.1017/s0007114515002810
  1. Yamadera, W., Inagawa, K., Chiba, S., Bannai, M., Takahashi, M., & Nakayama, K. (2007). Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes. Sleep and Biological Rhythms, 5(2), 126-131. https://doi.org/10.1111/j.1479-8425.2007.00262.x
  1. Clark, K. L., Sebastianelli, W., Flechsenhar, K. R., Aukermann, D. F., Meza, F., Millard, R. L., Deitch, J. R., Sherbondy, P. S., & Albert, A. (2008). 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Current Medical Research and Opinion, 24(5), 1485-1496. https://doi.org/10.1185/030079908×291967
  1. Kawada, C., Yoshida, T., Yoshida, H., Matsuoka, R., Sakamoto, W., Odanaka, W., Sato, T., Yamasaki, T., Kanemitsu, T., Masuda, Y., & Urushibata, O. (2014). Ingested hyaluronan moisturizes dry skin. Nutrition Journal, 13(1). https://doi.org/10.1186/1475-2891-13-70
  1. Carreiro, A. L., Dhillon, J., Gordon, S., Higgins, K. A., Jacobs, A. G., McArthur, B. M., Redan, B. W., Rivera, R. L., Schmidt, L. R., & Mattes, R. D. (2016). The macronutrients, appetite, and energy intake. Annual Review of Nutrition, 36(1), 73-103. https://doi.org/10.1146/annurev-nutr-121415-112624
  1. Wijnands, K., Castermans, T., Hommen, M., Meesters, D., & Poeze, M. (2015). Arginine and citrulline and the immune response in sepsis. Nutrients, 7(3), 1426-1463. https://doi.org/10.3390/nu7031426
  1. Kawai, N., Sakai, N., Okuro, M., Karakawa, S., Tsuneyoshi, Y., Kawasaki, N., Takeda, T., Bannai, M., & Nishino, S. (2014). The sleep-promoting and Hypothermic effects of glycine are mediated by NMDA receptors in the Suprachiasmatic nucleus. Neuropsychopharmacology, 40(6), 1405-1416. https://doi.org/10.1038/npp.2014.326
  1. INAGAWA, K., HIRAOKA, T., KOHDA, T., YAMADERA, W., & TAKAHASHI, M. (2006). Subjective effects of glycine ingestion before bedtime on sleep quality. Sleep and Biological Rhythms, 4(1), 75-77. https://doi.org/10.1111/j.1479-8425.2006.00193.x
  1. Wu, G., Bazer, F. W., Burghardt, R. C., Johnson, G. A., Kim, S. W., Knabe, D. A., Li, P., Li, X., McKnight, J. R., Satterfield, M. C., & Spencer, T. E. (2010). Proline and hydroxyproline metabolism: Implications for animal and human nutrition. Amino Acids, 40(4), 1053-1063. https://doi.org/10.1007/s00726-010-0715-z
  1. Barbul, A. (2008). Proline precursors to sustain mammalian collagen synthesis. The Journal of Nutrition, 138(10), 2021S-2024S. https://doi.org/10.1093/jn/138.10.2021s
  1. Karna, E., Szoka, L., Huynh, T. Y., & Palka, J. A. (2019). Proline-dependent regulation of collagen metabolism. Cellular and Molecular Life Sciences, 77(10), 1911-1918. https://doi.org/10.1007/s00018-019-03363-3
  2. McRae, M. P. (2016). Therapeutic benefits of L-arginine: An umbrella review of meta-analyses. Journal of Chiropractic Medicine, 15(3), 184-189. https://doi.org/10.1016/j.jcm.2016.06.002
  1. Stechmiller, J. K., Childress, B., & Cowan, L. (2005). Arginine supplementation and wound healing. Nutrition in Clinical Practice, 20(1), 52-61. https://doi.org/10.1177/011542650502000152
  1. Vasdev, S., & Gill, V. (2008). The antihypertensive effect of arginine. International Journal of Angiology, 17(01), 07-22. https://doi.org/10.1055/s-0031-1278274
  1. Farah, A., Monteiro, M., Donangelo, C. M., & Lafay, S. (2008). Chlorogenic acids from green coffee extract are highly bioavailable in humans. The Journal of Nutrition, 138(12), 2309-2315. https://doi.org/10.3945/jn.108.095554
  1. Meng, S., Cao, J., Feng, Q., Peng, J., & Hu, Y. (2013). Roles of Chlorogenic acid on regulating glucose and lipids metabolism: A review. Evidence-Based Complementary and Alternative Medicine, 2013, 1-11. https://doi.org/10.1155/2013/801457
  1. Roshan, H., Nikpayam, O., Sedaghat, M., & Sohrab, G. (2018). Effects of green coffee extract supplementation on anthropometric indices, glycaemic control, blood pressure, lipid profile, insulin resistance and appetite in patients with the metabolic syndrome: A randomised clinical trial. British Journal of Nutrition, 119(3), 250-258. https://doi.org/10.1017/s0007114517003439
  1. Onakpoya, I., Terry, R., & Ernst, E. (2011). The use of green coffee extract as a weight loss supplement: A systematic review and meta-analysis of randomised clinical trials. Gastroenterology Research and Practice, 2011, 1-6. https://doi.org/10.1155/2011/382852
  1. Tajik, N., Tajik, M., Mack, I., & Enck, P. (2017). The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: A comprehensive review of the literature. European Journal of Nutrition, 56(7), 2215-2244. https://doi.org/10.1007/s00394-017-1379-1
  1. Asbaghi, O., Sadeghian, M., Nasiri, M., Khodadost, M., Shokri, A., Panahande, B., Pirouzi, A., & Sadeghi, O. (2020). The effects of green coffee extract supplementation on glycemic indices and lipid profile in adults: A systematic review and dose-response meta-analysis of clinical trials. Nutrition Journal, 19(1). https://doi.org/10.1186/s12937-020-00587-z
  1. Huxley, R. (2009). Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus. Archives of Internal Medicine, 169(22), 2053. https://doi.org/10.1001/archinternmed.2009.439
  1. Watanabe, T., Arai, Y., Mitsui, Y., Kusaura, T., Okawa, W., Kajihara, Y., & Saito, I. (2006). The blood pressure-lowering effect and safety of Chlorogenic acid from green coffee bean extract in essential hypertension. Clinical and Experimental Hypertension, 28(5), 439-449. https://doi.org/10.1080/10641960600798655
  1. Fukagawa, S., Haramizu, S., Sasaoka, S., Yasuda, Y., Tsujimura, H., & Murase, T. (2017). Coffee polyphenols extracted from green coffee beans improve skin properties and microcirculatory function. Bioscience, Biotechnology, and Biochemistry, 81(9), 1814-1822. https://doi.org/10.1080/09168451.2017.1345614
  2. Mohamed, H. E., Asker, M. E., Younis, N. N., Shaheen, M. A., & Eissa, R. G. (2018). Modulation of brain insulin signaling in Alzheimer’s disease: New insight on the protective role of green coffee bean extract. Nutritional Neuroscience, 23(1), 27-36. https://doi.org/10.1080/1028415x.2018.1468535
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